Pluronic® F127 하이드로젤과 규산칼슘 하이브리드 골수복재의 탐색 연구
Investigational Study of Hybrid Bone Graft Materials with Calcium Silicate and Pluronic® F127-based Hydrogel
노지연, 김광만,
소속 상세정보
노지연 ( Roh Ji-Yeon ) - 연세대학교 원주의과대학 치위생학과
김광만 ( Kim Kwang-Mahn ) - 연세대학교 치과대학 치과생체재료공학교실
KMID : 1035320160430010073
Abstract
Calcium silicate cement, which is known as Mineral trioxide aggregate, usually mixed with distilled water. It showed limitation in manipulation and setting mechanism. To overcome its character, we modified the liquid to thermoreversible hydrogel, F-127. So, we developed hybrid bone graft materials with calcium silicate and hydrogel. And we measured their phase transition temperature using differential scanning calorimetry (DSC) and evaluated physical properties, film thickness, surface texture, ability to manipulation and flow change according to temperature change. Various concentration of hydrogel (5, 10, 20, 30 and 40 wt%) was mixed with calcium silicate cement in 1:0.3 ratios and was coded H5, H10, H20, H30 and H40. The original calcium silicate cement with distilled water was used as control (MDW). To evaluate their physical characteristics, film thickness was measured according to ISO 9917-1 and surface texture and flow properties were compared. As the concentration of F-127 increased, the transition temperature was decreased. In H20 and H30 showed significantly lower film thickness with creamy texture and gelation at 37℃. In conclusion, the hybrid with hydrogel and calcium silicate cement, especially H20 and H30, was candidate combinations might be a candidate as useful bone graft materials.
키워드
Calcium silicate cement; Thermoreversible Hydrogel; F127; Bone graft materials; Physical properties
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